如何大力加强抗菌药物临床应用管理.ppt

* Harbarth and colleagues performed an observational 4-year cohort study involving 2,641 patients at a tertiary-care center who had undergone coronary artery bypass grafting (CABG). The results showed that prolonged antibiotic prophylaxis (48 hours) was not associated with a decreased risk of SSI (adjusted odds ratio [OR], 1.2; 95% confidence interval [CI], 0.8–1.6) compared with a short (48 hours) course. Furthermore, prolonged antibiotics were correlated with an increased risk of acquired antibiotic resistance (adjusted OR, 1.6; CI, 1.1–2.6).1 Multivariate analysis identified 4 variables tha