2、Cell 2015-BRAF假基因作为竞争性内源性RNA发挥作用并在体内诱导淋巴瘤.pdf

Article The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo Graphical Abstract Authors Florian A. Karreth, Markus Reschke, ..., Roberto Chiarle, Pier Paolo Pandolfi Correspondence ppandolf@ In Brief The in vivo evidence for the regulatory activity of pseudogenes has been lacking, and their role in disease progression has been correlative. This study now shows that transgenic expression of the BRAF pseudogene induces a malignancy in mice resembling human diffuse large B cell lymphoma, establishing its oncogenic function. Highlights d The BRAF pseudogene functions as a ceRNA for BRAF in humans and mice d Braf-rs1 overexpression promotes B cell lymphoma in mice d Silencing of BRAFP1 affects MAPK signaling and proliferation of human cancer cells d Genomic gains and abe