阿司匹林抵抗的概念缺乏临床意义.pptxVIP

阿司匹林抵抗的概念缺乏临床意义301医院 陈韵岱动脉粥样硬化-血栓形成：进展性过程 斑块破裂血栓形成不稳定心绞痛脂肪条纹正常纤维斑块粥样硬化斑块心肌梗死缺血性卒中 /短暂缺血发作下肢缺血无临床症状稳定性心绞痛间歇性跛行心血管病死亡血栓形成是心脑血管事件的发病基础年龄增长阿司匹林氯吡格雷血小板激活通道凝血酶血栓素A2ADP血小板纤维蛋白结合位点纤维蛋白原血小板激活阿司匹林一级预防：汇总分析（致死和非致死的心肌梗死）StudyAspirin (%) Control (%)RRP-value95% CIBDT169/3429 (4.9)88/1710 (5.1)0.960.740.75~1.23HOT*157/9399 (1.7)184/9391 (2.0)0.850.140.69~1.05PHS139/11037 (1.3)239/11034 (2.2)0.580.00010.47~0.72PPP19/2226 (0.9)28/2269 (1.2)0.690.210.39~1.23TPT*154/2545 (6.1)190/2540 (7.5)0.810.040.66~0.99Total*638/28636 (2.2)729/26944 (2.7)0.770.00010.69~0.85* Silent MIs included.The relative risk, p-value