合成化学课件lecture1 for PDF.docVIP

word文档可编辑 Synthetic Chemistry Instructor：Bo Liu Email: imliuboliubo@126.com Synthetic Chemistry-Lecture 12 Synthetic Chemistry ?Organic Synthesis ?Inorganic Synthesis ?Macromolecular Synthesis ?Biochemical Synthesis Synthetic Chemistry-Lecture 13 References ?现代有机合成化学吴毓林、姚祝军, 科学出版社 ? Modern Organic Chemistry D. Boger, the Scripps Research Institute ? Advanced Organic Chemistry J. March, John Wiley Sons Inc. ? The Logic of Chemical Synthesis E. J. Corey and X. M. Cheng, John Wiley Sons Inc. ?Frontier Orbitalsand Organic Chemical Reactions I. Fleming, John Wiley Sons Inc. Synthetic Chemistry-Lecture 14 Synthesizing our future RyojiNoyori, Nature Chemistry , 2009, 1 , 5-6 ?Chemistry attempts both to understandthe structures and characteristics of substances in minute detailsat the atomic and molecular levels, and to createnew compounds with desirable properties and functions. ?Chemistryhas a centralrole in science, and synthesishas a centralrole in chemistry. Synthetic Chemistry-Lecture 15 Synthesis: Crucial to Medicine ?“B”Biological; isolated from an organism/cell line or produced by biotechnological ?“N”Natural product. ?“ND”Derived from a natural product and is usually a semisyntheticmodification. ?“S”Totally synthetic drug ?“S*”Made by total synthesis, but the pharmacophoreis/was from a natural product. ?“V”Vaccine; “NM”Natural product mimics J. Nat. Prod. 2007, 70, 461-477 All new chemical entities, 01/1981-06/2006, by source (N ) 1184). Synthetic Chemistry-Lecture 16 What is Organic Synthesis? Chemical Synthesis: Intentional construction of molecules by means of chemical reactions Organic Synthesis: Intentional construction of organic molecules by means of organic reactions Synthetic Chemistry-Lecture 17 Organic Synthesis Classifications Synthetic Chemistry-Lecture 18 Why Synthesize Organic Molecules? Synthetic Chemistry-Lecture 19 A Compressed History of Synthesis Synthetic Chemistry-Lecture 110 1940-1980, The Woodward Era Synthetic