氨基酸保护基的最新力作_图文.docVIP

Subscriber access provided by SHANDONG UNIV Chemical Reviews is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Review Amino Acid-Protecting Groups Albert Isidro-Llobet, Mercedes A#lvarez, and Fernando Albericio Chem. Rev., Article ASAP ? DOI: 10.1021/cr800323s ? Publication Date (Web: 13 April 2009 Downloaded from on April 26, 2009 More About This Article Additional resources and features associated with this article are available within the HTML version:?Supporting Information ?Access to high resolution figures ?Links to articles and content related to this article ?Copyright permission to reproduce figures and/or text from this article Amino Acid-Protecting Groups Albert Isidro-Llobet,?Mercedes A′lvarez,*,?,?,§and Fernando Albericio*,?,?,| Institute for Research in Biomedicine,Barcelona Science Park,Baldiri Reixac10,08028Barcelona,Spain;CIBER-BBN,Networking Centre on Bioengineering,Biomaterials and Nanomedicine,Barcelona Science Park,Baldiri Reixac10,08028Barcelona,Spain;Laboratory of Organic Chemistry,Faculty of Pharmacy,University of Barcelona,08028Barcelona,Spain;and Department of Organic Chemistry,University of Barcelona, Mart?′i Franque′s1,08028Barcelona,Spain Received April28,2008 Contents 1.Introduction B 2.R-Amino C 2.1.General C 2.2.Introduction of the Protecting Groups C 2.3.Removal C 2.3.1.Protecting Groups Removed by Acid (Table1 C 2.3.2.Protecting Groups Removed by Base (Table2 E 2.3.3.Other Protecting Groups(Table3F 3.Lysine(Lys,Ornithine(Orn,Diaminopropionic Acid(Dap,and Diaminobutyric Acid(Dab I 3.1.General I 3.2.Introduction of the Protecting Groups L 3.3.Removal M 3.3.1.Protecting Groups Removed by Acid (Table5 M 3.3.2.Protecting Groups Removed by Base (Table6 M 3.3.3.Other Protecting Groups(Table7M 4.R-Carboxylic Acid M 4.1.General M 4.2.Introduction of the Protecting Groups N 4.3.Removal N 4.3.1.Protecting Groups Removed by Acid (Table8 N 4.3.2.Protecting Groups Removed by Base (Table9 O 4.3.3.