细菌耐药现状与耐药机制分析详解.pptVIP

细菌耐药现状和耐药机制分析 倪语星  流行病学  Epidemiology Mortality Associated with Inappropriate Empiric Therapy Pa001 619% P0.001 284% 0 All cause Infection related 口 Appropriate口 Inappropriate Reference: Ibrahim EH et al. Chest 2000: 118: 146-1  Epidemiology 19505-Penicillin-R Staph aureus  s 990s-VRE, VRSA, VRSE  Epidemiology Prevalence of Antimicrobial-Resistant(R) Pathogens Causing Hospital-Onset Intensive Care Unit Infections: 1999 versus 1994-98 Isolates Increase Fluoroquinolone-R Pseudomonas spp. 3rd generation cephalosporin-R E coli 1551 48% Methi cil lin-R Staphylococcus aureus 2546 40% Vancomycin-R enterococci Imipenem-R Pseudomonas spp. 1839 20% Percent increase in proportion of pathogens resistant to indicated antimicrobial Saurce:Nationa Nosocomial Infections Survellance (NNIS)Sydtem CDC Link to: wws Orwe at coc  Epidemiology Bacterial Resistance in the Community and the Hospital Hospital Community VRE VRSA ESBLS Pseudo。nas Salmonella spp. deraiL。sa M. tuberculosis N- gonorrheae  2002年全国17家医院主要革兰阴性菌分布 POOL OF china, Gram-Negative isolates, N= 2013, Patients =1749 entnoonas matophwa 0535340735570乃 0365985408  06000D 0020700570 户ho5 0D 100 100 ed on AB BoDsk E-Test MICs  2002年全国17家医院革兰阴性菌敏感性 Percentage Susceptibility: Pool Of China Gram-Negative isolates N= 2013 Pts= 1749 泰能他啶舒普噻肟曲松匹肟特治特美庆大丁卡环丙 深 星汀  革兰阴性菌主要耐药菌构成 Non Susceptible Isolates Distribution Pool Of China: Gram-Negative isolates, N=2013 Pts =1749 Others Acinetobact spp Enterobact Klebsiella spp Cefta- Cefp/ Cefi Genta zidane tazobact mIcIn ew NCCLS ESEL Bpts freundT M. morgani