《基础医学各论II》课件：消化系统药理学.pdfVIP

Drugs Used in the Treatment of Drugs Used in the Treatment of Gastrointestinal Diseases Gastrointestinal Diseases Yun-Bi Lu, PhD Yun-Bi Lu, PhD 卢韵碧 卢韵碧 Dept. of Pharmacology, Dept. of Pharmacology, School of Medicine, Zhejiang University School of Medicine, Zhejiang University yunbi@zju.edu.cn yunbi@zju.edu.cn 1. Hepatic, pancreatic 1. Hepatic, pancreatic and biliary disorders and biliary disorders 2. Acid-peptic disorders 3.Gastrointesinal motility Disorders 4. Inflammatory bowel diseases Gastrointestinal drugs A. Drugs used for acid-peptic A. Drugs used for disorders (抗消化性溃疡药) disorders B. Modulators of gastrointestinal B. Modulators of gastrointestinal functions (消化功能调节药) functions (消化功能调节药) Symptoms: Upper abdominal burning or hunger pain Emesia (呕吐), belching (嗳气) The feature of peptic ulcer disease: High incidence, frequent Recurrence, Drug therapeutics is the main way for treatment. Ulcer complication Ulcer bleeding ( 出血) Ulcer perforation (穿孔) Pyloristenosis (幽门狭窄) Canceration (癌变) Mucus-bicarbonate barrier acid-peptic disorders Aggressive factors Defensive factors Gastric acid Mucus Gastric acid Pepsin bicarbonate Pepsin Helicobacter pylori Mucosa Helicobacter pylori Acid-peptic disorders 1) Peptic ulcer disease (PUD) chronic inflammation due to Helicobacter pylori 2) Drug-induced mucosal injury, e