围绝经期冠心病的临床和冠脉造影特点及其介入治疗的疗.doc

【摘要】 目的： 探讨围绝经期女性冠心病患者的临床特点、危险因素、冠脉造影特点及介入治疗疗效，为早期发现女性冠心病，并对其防治提供依据。方法：因怀疑冠心病入院的围绝经期女性113例，根据造影结果分为冠心病组(45例)和正常对照组(68例)，比较两组临床症状，危险因素，造影特点及介入治疗的疗效。结果：冠心病组患者有高血压(68.9%∶27.9%)、糖尿病(75.6%∶39.7%)、家族史(66.7%∶30.9%)，同时具有≥2个冠心病危险因素的患者(57.8%∶26.4%)明显高于正常对照组(P0.05)。冠心病组中单支病变28例(62.2%)，双支病变12例(26.7%)，三支病变5例(11.1%)。21例冠心病患者行介入治疗均获得成功，随访期间，无主要不良心血管事件发生。结论：高血压，糖尿病、家族史及同时具有多个冠心病危险因素是围绝经期女性冠心病的最主要特点;围绝经期女性冠心病多为简单病变，介入治疗预后较好。 【关键词】 冠状动脉疾病;围绝经期;冠状血管造影术;血管成形术，经腔，经皮冠状动脉 　　Abstract：Objective：To explore clinical features， risk factors， characteristics of coronary angiography and its therapeutic effects of percutaneous coronary intervention (PCI) in perimenopause female patients with coronary heart disease (CHD). Methods：According to results of coronary angiography， a total of 113 perimenopause female patients suspected CHD were divided into CHD group (n=45) and normal control group (without CHD，n=68). Clinical features， risk factors， characteristics of coronary angiography and therapeutic effects of PCI of the two groups were compared and analyzed. Results： For the CHD group，the incidence rates of hypertension (68.9% vs. 27.9%)， diabetes (75.6% vs. 39.7%)， CHD family history (66.7% vs. 30.9%) and patients possessed ≥2 risk factors of CHD were significantly higher than those of normal control group (P0.05 all). In CHD group， there were 28 cases (62.2%) of single-vessel coronary disease， 12 cases (26.7%) of double-vessel coronary disease and five cases (11.1%) of triple-vessel coronary disease. A total of 21 CHD patients successfully received PCI and there were no main adverse cardiovascular events during follow-up period. Conclusion： Hypertension， diabetes， CHD family history and possession of multiple risk factors of CHD are main features of perimenopause female with CHD; most of these patients are single-vessel coronary disease， which can get a better prognosis after PCI. 　　Key words：Coronary artery disease; Perimenopause; Coronary angiography; Angioplasty， transluminal， percutaneous