难治性癫痫的定的义及原因.pptVIP

难治性癫痫的定义 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  难治性癫痫在癫痫综合征 中无分类。 是指临床症状迁延不愈, 应用恰当的一线药物正规治疗 且药物血浓度在有效范围内, 仍有每月四次发作以上的,无 严重药物副反应的,经两年治 疗仍无效的。 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  要排除的是:1、大脑无 进行性病变,包括肿瘤,变 性病等;2、诊断错误;3、 用药不当;4、用量不足;5 治疗依从性差(包括忘药 断药,饮酒,刺激性活动, 经济原因) Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  二、难治癫痫的原因 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  医源性 1、诊断错误 分类错误 3、选药错误; 4、依从性差(医患双方) Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  真正的IE的机制 1、遗传性 2、基因因素、7号染色体 3、耐药与多耐药(MDR) P糖蛋白(PGP)耐受分为 (20世纪70年代): 先天性耐受 功能性耐受或代谢性耐受 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  4、海马硬化 5、皮质发育不良 6、神经元凋亡 7、反应性胶质增生而导致神 经网络重组信号传导异常 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  耐药蛋白的作用机制 PGP能阻止药物进入血脑 屏障 PGP能将已进入的药物泵 出血脑屏障 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  三、难治性癫痫的治疗 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  NEW he effective single-dose solution m Indicated for the treatment of u