盐酸多奈哌齐治疗轻中度阿尔茨海默病的临床评估.docVIP

pat i e np r o d u c1 i t y o f ted and pat i e np r o d u c1 i t y o f ted and AD, I t c o t i o n andwell I o 1 [Key words] Hydrochlor ide, Ani r a 盐酸多奈哌齐治疗轻中度阿尔茨海默病的临床评估 【摘要】目的评价盐酸多奈哌齐治疗轻、中度阿尔茨海默病(Alzheimer d i s ease, AD)的有效性及安全性。方法选择简易智能状态量表(MMSE) 1 0?2 4分的轻、中度AD患者6 4例，按随机原则分成治疗纽和对照组各3 2例，治疗组给予盐 酸多奈哌齐治疗，对照组给予茴拉西坦治疗，观察1 2周。治疗前后应用MMS E,日當生 活能力最表(A D L )评价临床疗效；用副反应最表(TESS)评定副反应。结果观察1 2周，盐酸多奈哌齐治疗纽?较对照纽.MMES、A D L评分明显改善(PVO. 0 1)。治 疗组盐酸多奈哌齐治疗1 2周后较治疗前MMS E与ADL分数分别改善3 . 9分和7 . 4 分(P0. 0 5 , P0 . 0 1 ),盐酸多奈哌齐治疗4周，MMS E分数已有提高(P V0. 0 5 ),故盐酸多奈哌齐起效时间在治疗4周末。盐酸多奈哌齐治疗纽不良反应轻， 与茴拉西坦对照纽比较两组差并无显著意义(P 0 . 0 5)。结论盐酸多奈哌齐能有效治 疗轻、中度A D患者，对患者的认知功能和日常生活自理能力均有改善，耐受性好，安全性 高。 【关键词】盐酸多奈哌齐 茴拉两坦 阿尔茨海默病 The S a f e t y and Efficacy o f D o n e p e z i 1 Hydro chloride i n Pat i e n t s with Alzheimer D i s e a s e (XU M i n , F ANG Q ? 1 D O N G Wan 1 i . D e P a r t m e n t 0 f n e uro 1 0 g y , The F 1 r s t H o s p i t a 1 A f f ilia t e d 0 f s u z h 0 u U n i ver s ■ 1 t y ,J 1 a n g j J u , s u z h o u , 2 1 5 0 0 6 9 c h i n a .) [A b s t i act ]0 b ? J e c t i v e T o a s s e s s the e f f i c a c y and s a f e t y 0 f a r i c e p t i n t r e a t m e n t o f m ? 1 1 d t o mode ra te Alzheimer disease(AD). Metho AD, w hd s 6 4 patients w i t h m i 1 d to moderat AD, w h a n d o m 1 y i n t 0 「 t r e a t m e n t g r 0 u P ( 3 2 ) a n d con t r 0 1 g r o u p (3 2 ), t r e a t m e n t group w e r e t r e a t e d w ■ 1 t h a r i c e P t f 0 r 1 2 w e e k s ,M M s E ,A D L a n d TESS w e r e use d a s s c a ling t 0 0 1 s . R e s u 1 t s MM S E a n d A D L s c o r e s o f a r i c e p t t r e a t m e n t g roup w e r e b e t t e r s 1 g n i f i c a n t t hen t h 0 s e 0 f c o n t r 0 1 g r o u p ( P 0 . 0 1 ), MMS E a n d A D L were r e s p e c t i V e o s e core of MMSE were 10 ?2 4 , were divided r 1 y 3 ? 9 a n d 7, ? 4 P o 1 n t s b y u s ■ 1 n g a r i c e p t 5 m g / d f 0 r 1 2 w e e k s , a s c o m p a r e d t 0 U 1 n t r e a t e d P a t i e n t s .T h e r e a r e 6 p a t i e n L