益生菌辅助干扰素治疗合并特应性体质小儿毛细支气管炎临床疗效及安全性探讨.docVIP

益生菌辅助干扰素治疗合并特应性体质小儿毛细支气管炎 临床疗效及安全性探讨 【摘要】目的:探讨益生菌辅助T扰素治疗合并特应性体质小儿毛细支气管炎临床疗效及安 全性。方法：研究对象选取我院2015年1月-2016年9月收治合并特应性体质小儿毛细支 气管炎患儿共100例，随机分为对照组（50例）和观察组（50例），分别给予干扰素单用和 在此基础上加用双歧杆菌三联活菌辅助治疗；比较两组患儿近期疗效，急性期病程，随访喘 息发作次数，治疗前后症状体征严重程度评分、呼吸频率、血氧饱和度、嗜酸性粒细胞 （EOS）、转化生长因子卩1 （TGF-pi）水平及不良反应发生率等。结果：对照组患儿治疗 后7d和治疗后6个月总有效率分别为74.00%, 60.0%；观察组患儿治疗后7d和治疗后6个 月总有效率分别为94.00%, 82.0%；观察组患儿治疗总有效率显著高于对照组（严0.05）； 观察组患儿急性期病程和随访喘息发作次数均显著优于对照组（〃0.05）；观察组患儿治疗 后7d和6个月症状体征严重程度评分显著低于对照组、治疗前（p0.05）:观察组患儿治 疗后7d和6个月呼吸频率、血氧饱和度、EOS及TGF-pi水平均显著优于对照组、治疗前 （严0.05）；同时两组患儿不良反应发生率比较差异无显著性（/X0.05） o结论：益生菌辅 助干扰索治疗合并特应性体质小儿毛细支气管炎可显著缩短急性期病程，降低再次发作风 险，减轻相关症状体征，改善肺部通气功能，调节EOS和TGF-pi水平，且未加重药物不 良反应。 【关键词】益生菌：干扰素：特应性体质；小儿毛细支气管炎；疗效；安全性 Clinical effects and safety investigation of probiotic assistedwith interferon in the treatment of atopic children withbronchiolitis Abstract: Objective To investigate the clinical effects and safety of probiotic assisted with interferon in the treatment of atopic children with bronchiolitis. Methods 100 atopic children with bronchiolitis were chosen in the period from January 2015 to September 2016 and「andomly divided into both group including control group (50 cases) with recombinant interferon a?2b used alone and observation group (80 cases) with live trigeminal bifidobacterium on the basis of control group; and the clinical efficacy for short-term, the diseases course of acute phase, the wheezing episodes number with follow-up, the severity scores of symptoms and signs, the levels of respiratory rate, oxygen saturation, EOS and TGF-pi before and after treatment and the adverse effects incidence of both groups were compared. Results The total clinical effects in 7d and 6 months after treatment of control group were separately 74.00%, 60.0%； the total clinical effects in 7d and 6 months after treatment of observation group were separately 94.00%，82.0%? The total clinical effects in 7d and 6 months after treatment of observation group were significantly higher than control group (p0.05)