小剂量雄激素治疗特发性少弱精子症的临床研究.doc

小剂量雄激素治疗特发性少弱精子症的临床研究 房磊臣I刘墻2 幸贵邦3 吴小候I 尹志康)何卫阳I 1.重庆医科大学附属第一医院泌屎外科(晝庆 400016)；2?海南医学院药学枕药理教研宣；3?重庆医科大学附属第一医院辅助生殖中心 摘要 目的 观察小剂复雄激囊治疗特发性少弱精子症的临床疗效。方法 从2005年10月至2008年3月 间.对258例特发性少弱精子症人群.分4组泊疗? A组37名，未服用药物治疗；B组98名，口眼硫酸锌 片50mg?毎日3次.维生素EJ9 lOOmg,毎F1 2次，中成药人味地黄丸5粒，毎日3次，疗程3个/b C组98名，在B组治疗药物的基础上，加用安特尔40mg,毎天一次，疗程3个月Dffl25名，为两次血 睾爾值均低于4ng/ml的总看，安恃尔40mg,每天两次，疗程3个月。结果 A 8118例、B组71例、C组 59例、D组19例宪成随访且进行复杳.C组箱液移数改善.血睾稠水平提高、配偶妊娠率均明显高于B组， 差异灯统计学意义(PV0.01》；D组在沦疗厉精液参数、血舉丽水平均较治疗前显薈增高，差舁有统计学 意义(P0.01〉?结论小剂做擦激素补充治疗町显着改善特发性少弱梢子症患者(尤英是血畢嗣水平低于 4ng/mI者)的糟液量、箱子密度、活动力、存活睾及血參銅水平，从而提高患者配偶的妊 关键词 不育；少精子症；弱梢子症； dol: 10.3969/j.issn.l008-0848.2012.02.012 中00分类号 R69 2 Small dose androgen in treatment of idiopathicoligo-asthe no spermatism Fang Leichen1, Liu Qing2, Xing Guibang\ Wu Xiaohou1*, Yin Zhikang1, He Weiyang1 L Department of Urology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016,China; 2. Department of Pharmacology. Hainan Medical College: 3. the Assist Reproduce Center, the First AffiliatedHospital of Chongqing Medical University Abstract Objective To investigate the effect of small dose androgen in the treatment of idiopathic oligo-asthcnospermatism. Methods The study was conducted from October. 2005 to March, 200 A total of 258 patients with indiopathic oligo-asthenospermatism were divided into 4 groups^ i.c. Group A (n=37. without any treatment) Group B(n=9 treated with Zinc Sulfate Tablets (50mg bid). Vitamin E (1 OOmg bid) and prepared herbal drugs (5 tablets tid), Group C (nT treated with Zinc Sulfate Tablets(50mg bid)t Vitamin E (lOOmg bid), prepared herbal drugs (5 tablets tid) and Testosterone Undecanoate Capsules (40mg qd), Group D (n?25, treated with Testosterone Undccanoate Capsules (40mg bid). The therapeutic course lasted for 3 months. Results Eighteen patients in Group A .71 in Group B. 59 in Group C and 19 in Group D were followed up successively. There was significant difference between Group B and Group C in semen parameters, levels of