药物合成反应课后翻译.docxVIP

四次把深色的油从混合物中用 四次把深色的油从混合物中用 150ml萃取岀来。The extracts are combined, washed About 216 — 224 g. — moles) of po wdered an hydrous aluminum chloride is added to a 1Lthree-necked flask.在1L的三口烧瓶中加入大约 216-224g - moles)的无水三氯化铝。 While the freeflow ing catalyst is stirred (Note 3), 81 g. mole) of acet ophenone is added from the dropping funnel in a slow stream over a p eriod of 20 -30 minutes. 自由流动 的催化剂边搅拌边用滴液漏斗缓慢滴加 81g 苯乙酰。Considerable heat is evolved, and, if the drops of ket one are not dis persed, darke ning or charri ng occurs. 放热反应，假如滴加 的酮不能被分散，就会变黑或是碳化。 When about o ne-third of the acetophenone has bee n added, the mixture becomes a viscous ball-like mass that is difficult to stir. 当三分之一的 乙酰苯被滴加，反应混合物变成一个很难搅拌的粘性的球状团块。 Turning of the stirrer by hand or more rapid additi on of ket one is n ecessary at this point. 在这时，改用手动搅 拌或快速滴加酮是非常必要的。 The addition of ketone, however, should not be so rapid as 180 180 C时。Near to produce a temperature above 180° .然而，速度不能太快，当反应温度超过 the end of the addition, the mass becomes molten and can be stirred easily without being 当快滴加完时，团块开始融化,either heated or cooled. The molte n mass, in which the acet ophenon e is complexed with aluminum chloride, ranges in color from tan to brown. 当快滴加完时，团块开始融化, 明苯乙酰已经和三氯化铝混合完全，颜色也逐渐从黄褐色变为棕色。 Bromine (128 g., mole) is added drop wise to the well-stirredmixture over a Bromine (128 g., mole) is added drop wise to the well-stirred mixture over a period of 40 minutes (Note 4). of 40 minutes (Note 4).在40分钟内在搅拌下把溴缓慢滴加到混合物中。 After all the bro mine has bee n added, the molte n mixture is stirred at 80-85° has bee n added, the molte n mixture is stirred at 80 -85° on a steam bath for 1 hour. 溴滴加完后，熔融混合物在 80-85 C蒸气浴下搅拌 溴滴加完后，熔融混合物在 80-85 C蒸气浴下搅拌1小时。The comp lex is added in po rti ons to a well-stirred mixture of l. of cracked ice and 100 ml. of concentrated hydrochloric acid in a 2-l. beaker (Note 6丄反应物加入到碎冰和 acid in a 2-l. beaker (Note 6丄 反应物加入到碎冰和 100ml浓盐酸的混合物中在 2L的烧杯中 混合均匀。 Part of the cold aqueous layer is added to the