病毒感染与免疫 英文 viral infection and immunity.ppt

Outline;Section 1 Viral pathogenesis;I. Transmission routes;;A. Horizontal transmission;civet cat;B. Vertical Transmission;Vertical Transmission;III. Virus Spread in the Host ;A. Local Replication Local Spread ;B. Dissemination from the Portal of Entry;Through Bloodstream;Through Nerves;II. Forms of viral infections ;Acute viral infection Persistent viral infection ; Natural history of acute and persistent human infections.;A. Chronic infection;B. Latent infection;Latency and recurrence in herpes simplex virus infections; Cold sores caused by herpes virus type 1 Recurrence of Latent virus infections ;;C. Slow virus infection;III. Pathogenesis of viral infections;Pathogenesis of viral infections;A. Direct damage to infected host cells;1. Cytocidal infection;CPE;;Rabies virus inclusion bodies;Polykaryocytes;2. Steady state infection;3. Integration and transformation;B. Immunopathological injury;Section IIAntiviral immunity;Antiviral immunity;I. Innate immunity;Innate immune factors against viral infection; a heterogeneous group of glycoproteins produced by human and other animal cells after viral infection (or after exposure to other inducers.) Functions of IFNs: anti-virus, anti-tumor, immunomodulation ;Innate Defenses ;Innate Defenses ;Interferon (IFN);Nonspecific Defenses ;;;NK cell;NK cell;II. Adaptive immunity;Humoral immunity Neutralizing antibody;Neutralizing Antibody;Virus infection without neutralizing Ab;;Cellular Immunity;Features: MHC-Ⅰrestriction Viral specificity Highly effective Late phase Mostly important factor in recovery from the viral infection ;Lysis of virus-infected cells by cytotoxic effector cells. ;Questions;