病毒性肝炎合并脂肪肝的治疗策略.ppt

代谢组学分析：丙肝患者和对照组存在差别 Classification of urine samples based on P function scores obtained through the metabonomics analysis of the 1H NMR spectra model of 66 individuals M. M. G. Godoy, et al. Journal of Viral Hepatitis, 2010, 17, 854–858 丙肝患者的核磁共振代谢组学 FFA促进HCV在肝细胞复制 Immunohistochemical staining for HCV core antigen in the infected Huh 7.5 cells in the presence of different concentrations of FAA after 15 days HCV infected Huh-7.5 cells were cultured with a mixture of saturated (palmitate) and unsaturated (oleate) long-chain free fatty acids (FFA). Intracytoplasmic fat accumulation in these cells was visualized by Nile red staining and electron microscopy then quantified by microfluorometry. The effect of FFA treatment on HCV replication and IFN-α antiviral response was measured by flow cytometric analysis, Renilla luciferase activity, and real-time RT-PCR Feyza Gunduz, et al. Virology Journal 2012, 9:143 游离脂肪酸降低IFN对HCV的治疗作用 HCV infected Huh-7.5 cells were cultured with a mixture of saturated (palmitate) and unsaturated (oleate) long-chain free fatty acids (FFA). Intracytoplasmic fat accumulation in these cells was visualized by Nile red staining and electron microscopy then quantified by microfluorometry. The effect of FFA treatment on HCV replication and IFN-α antiviral response was measured by flow cytometric analysis, Renilla luciferase activity, and real-time RT-PCR Feyza Gunduz, et al. Virology Journal 2012, 9:143 IR降低抗病毒治疗病毒学应答率：EVR HOMA：稳态模式评估法，Homeostasis Model Assessment，用于评估胰岛素抵抗。 J . J . BLONSKY S. A. HARRISON. Aliment Pharmacol Ther 27, 855–865 To conduct a systematic, evidence-based review of the epidemiology, pathophysiology and potential treatments of coexistent NAFLD and CHC. The terms such as hepatitis C, fatty liver, NAFLD, nonalcoholic steatohepatitis and steatosis were searched on PubMed up to January 2008. References from selected articles and pertinent abstracts were also included. IR降低抗病毒治疗病毒学应答率：SVR HOMA：稳态模式评估法，Homeostasis Model Assessment，