年产0.9亿腺苷钴胺片（25mg）车间工艺设计.docx

年产0.9亿腺苷钴胺片（25mg）车间工艺设计 中文摘要：腺苷钴胺片作为一种常见的维生素类药，在国内有着很大的市场。通过研究腺苷钴胺片的生产工艺及其车间设计并进行优化，可以极大的缩减原材料及车间面积，从而提高企业利润。腺苷钴胺片的片重100mg,其中主料腺苷钴胺25mg淀粉和微晶纤维素作为填充剂各占30%和20%，20%的打浆淀粉作为粘合剂，4%的羟甲基淀粉钠为崩解剂，1%的滑石粉为润滑剂，以此确定腺苷钴胺片的处方，进行物料衡算。每一万粒腺苷钴胺片需要0.25Kg腺苷钴胺，0.2Kg打浆淀粉，0.3Kg淀粉，0.2Kg微晶纤维素，0.04Kg羟甲基淀粉钠，0.01Kg滑石粉。根据以上进行设备选型和单元操作车间面积的布置。单元操作车间的布置采用U型排列，总车间长36米，宽24米。 关键词：腺苷钴胺片；生产工艺；车间布置；空调系统  摘要：As a common kind of vitamin pills, The Cobamamide Table has a large market. we can reduce the workshop area and the consumption of the raw material through study of the production process and workshop design of the Cobamamide Table. Then the profit of enterprises will improve greatly. The weight of Cobamamide Table is 100mg , in which the cobamamide is 25mg .As the filler ,starch accounted for 30% and microcrystalline cellulose accounted for 20%.The beating starch accounted for 20% as adhesive. The carboxymethyl starch sodium accounted for 4% as the disintegrating agent. The talc accounted for 1% as the lubricant. Account to the calculation result of material balance: There are 0.25Kg of Cobamamide ,0.2Kg of beating starch ,0.3Kg of the starch,0.2Kg 0f the microcrystalline cellulose, 0.04Kg of the carboxymethyl starch sodium and 0.01Kg of the talc in ten thousand of Cobamaide tables. The selection of equipment and the distribution of workshop area can be in progress. The length of the workshop is 36 meter, the width is 24 meters. 关键词: Cobamaide tables; Production process; Workshop design: Air conditioning system  目录 引言 片剂…………………………………………………………………1 腺苷钴胺片的简介…………………………………………………2 设计的目的及意义…………………………………………………2 1．指导思想和设计原则 1.1 指导思想…………………………………………………………3 1.2 设计原则…………………………………………………………3 1.2.1 工艺流程设计………………………………………………3 1.2.2设备选型及制剂车间的设计………………………………3 1.2.3 空调净化系统设计…………………………………………4 2.工艺流程设计 2.1 概述………………………………………………………………5 2.2 制剂工程设计的基本要求………………………………………5 2.3 工艺设计方案……………………………………………………5 2.3.1 设计参数……………………………………………………5 2.3.2 腺苷钴胺片的配料比………………………………………6 2.4 生产工艺流程框图………………………………………………6 3.物料衡算 3.1 生产能力…………………………