年产8000万盒盐酸左氧氟沙星胶囊的车间工艺设计.doc

年产8000万盒盐酸左氧氟沙星胶囊（规格0.1g*12粒/盒）的车间 工艺设计 摘要：近年来，无论是国际市场还是国内市场，左氧氟沙星都呈热销态势，销售额连年大幅增长，制成胶囊剂能掩盖药物不良气味，提高药物稳定性。盐酸左氧氟沙星的主要作用机制为抑制细菌DNA旋转酶的活性，阻碍细菌DNA复制，具有抗菌谱广、抗菌作用强的特点。适用于敏感细菌引起的轻、中度感染，如呼吸系统感染、泌尿系统感染、生殖系统感染、皮肤软组织感染等。本设计主要从车间设计原则与指导思想、生产工艺流程、物料衡算、设备的选型、车间平面布置、空调净化系统和环境保护等多方面体现盐酸左氧氟沙星胶囊的车间工艺设计。本次设计的生产工艺简单，比较适合中小型企业生产。 关键词：左氧氟沙星 胶囊剂 工艺流程 车间布置 Annual output of 80 million boxes of levofloxacin hydrochloride capsules in the workshop Process design(specification:0.1g*12/box) Abstract: In recent years, both in the international market and domestic market, levofloxacin is sell like hot cakes, sales growth for years, made into capsule drugs can cover up the bad smell, improve drug stability.The main effect of levofloxacin hydrochloride mechanism for inhibiting bacterial DNA gyrase activity, inhibiting bacterial DNA replication, has the characteristics of wide antimicrobial spectrum, strong antibacterial activity.Suitable for light, moderate infections caused by sensitive bacteria, such as respiratory system infection, urinary tract infection, infection of the reproductive system, skin and soft tissue infection, etc.The design principles and guiding ideology, mainly from the workshop production process, material balance, equipment selection, shop layout, air conditioning purification system and environmental protection and other aspects of levofloxacin hydrochloride capsules workshop process design.The design of simple production technology, suitable for small and medium-sized enterprise production. Keywords: levofloxacin; capsule; process; workshop layout 目录 TOC \o 1-3 \h \z \u 19948 引 言 1 30156 1、胶囊剂的概述 1 6177 2、盐酸左氧氟沙星胶囊 2 10426 第一章 指导思想和设计原则 4 32725 1.1 指导思想 4 20671 1.2 设计原则 4 18563 1.2.1 厂区的选择和布置 4 6687 1.2.2 工艺流程 4 20809 1.3 设备的选型 5 25536 1.4 制剂车间的布置 5 4266 1.5 空调净化系统 5 30827 第二章 工艺流程设计 6 25434 2.1 工艺设计参数 6 13033 2.1.1 产品方案 6 27700 2.1.2 生产计划 6 5849 2.2生产工艺设计 6 19483 2.2.1粉碎筛分 6 26356 2.2.2混合 7 6143 2.2.3 制粒 7 11208