年产4万吨吲哚洛尔原料药的生产工艺设计.docx

年产4万吨吲哚洛尔原料药的生产工艺设计 摘要：本设计主要探讨1973年瑞士Sandoz公司开发的β受体阻断剂-吲哚洛尔。探讨吲哚洛尔的分子结构式，物理化学性质，简介，发展前景，适应症，药效药理作用，急慢性毒性，临床副作用等。设计吲哚洛尔的工业化生产工艺流程、生产工艺设计，并对其进行物料衡算和能量衡算，做出工业化生产的工艺图纸，包括反应设备图，工艺流程图，车间平面图。确定整个工业化生产所需要的各种反应设备，包括型号、功率、容量等。同时考虑到“三废”处理，注重环境保护。对工业化生产的生产能力做出估算。 关键词：吲哚洛尔；工艺流程；三废处理；生产能力  The production process design of annual production capacity of 40000 tons of Pindolol enteric-coated tablets Abstract：Designed to explore the 1973 Swiss company Sandoz development of the beta receptor antagonist - Pindolol. Pindolol explore the molecular structure, physical and chemical properties, briefings, and the prospects for development, indications, pharmacological effect, acute and chronic toxicity, the clinical side effects. Design Pindolol industrialized production process, the production process design, and its material balance and energy balance. make the production process of industrialization drawings to determine the entire industrial production needs of the response equipment, including models, power, such capacity. On the industrialized production capacity estimated. Keywords : Pindolol; Technology; polution treatment; Productivity 目录 引言.............................................................................................................1 指导思想和设计原则.........................................................................3 1.1指导思想...............................................................................................3 1.2 设计原则..............................................................................................3 1.2.1 厂区的选择和布置.............................................................................3 1.2.2 工艺流程 .........................................................................................4 1.2.3 物料衡算与能量衡算 ........................................................................4 1.2.4 设备的选型.......................................................................................4 1.2.5 原料药车间的布置..............