HPV联合细胞DNA定量检查及血清SCC在宫颈癌筛查及预后中的意义.docVIP

HPV联合细胞DNA定量检查及血清SCC在宫颈癌筛查及预后中的意义 打开文本图片集 【摘要】 目的：探究HPV联合细胞DNA定量检查及血清SCC在宫颈癌筛查及预后中的意义。方法：选取2012年12月-2017年12月本院收治的98例宫颈癌患者为A组，同时期的98例高度鳞状上皮内病变（high-grade squamous intraepithelial lesion，HSIL）患者为B组，98例低度鳞状上皮内病变（low-grade squamous intraepithelial lesion，LSIL）患者为C组，98例体检健康妇女为D组。比较四组HPV、细胞DNA定量检查及血清SCC阳性率，同时比较A组中不同分期与分化程度宫颈癌患者的阳性率。结果：A组与B组HPV、细胞DNA定量检查比较，差异均无统计学意义（Pgt;0.05），但均高于C组和D组，A组血清SCC阳性率高于其他三组，差异有统计学意义（Plt;0.05），但A组中不同分期与分化程度宫颈癌患者HPV、细胞DNA定量检查比较，差异均无统计学意义（Pgt;0.05），但血清SCC阳性率比较，差异有统计学意义（Plt;0.05）。结论：宫颈癌患者的HPV、细胞DNA定量检查及血清SCC结果明显异常，但对疾病分期与分化程度无明显意义。 【关键词】 HPV; 细胞DNA定量检查; 血清SCC; 宫颈癌; 预后 【Abstract】 Objective：To investigate the significance of HPV combined with cellular DNA quantitative examination and serum SCC in the screening and prognosis of cervical cancer.Method：98 patients with cervical cancer from December 2012 to December 2017 were chosen as group A，98 patients with high-grade squamous intraepithelial lesion（HSIL）at the same time were chosen as group B，98 patients with low-grade squamous intraepithelial lesion（LSIL）were chosen as group C，98 healthy women were chosen as group D.Then the positive rates of HPV，cellular DNA quantitative examination and serum SCC of four groups were compared，then the positive rates of group A with different stages and differentiation of cervical cancer were compared.Result：The HPV and cellular DNA quantitative examination of group A and group B were compared，there were no statistically significant differences（Pgt;0.05），they were higher than those of group C and group D，the serum SCC positive rates of group A were higher than those of three groups，there were all statistically significant differences（Plt;0.05），while the HPV and cellular DNA quantitative examination of group A with different stages and differentiation of cervical cancer were compared，there were no statistically significant differences（Pgt;0.05），and the serum SCC positive rates were compared，there were all statistically significant differences（Plt;0.05）.Conclusio