详述高级病生次RegulatoryeffectofST.pptVIP

* * * * * * AIMS To clarify whether ST2 negatively regulates TLR2 signaling To examine whether ST2 is a key molecule for inducing BLP tolerance  Enhanced TNF? production is observed in BLP-stimulated ST2-deficient macrophages Part 1: To clarify whether ST2 negatively regulates TLR2 signaling Part 1: To clarify whether ST2 negatively regulates TLR2 signaling Overexpression of ST2 attenuates BLP-stimulated NF-?B activation in HEK293-TLR2 cells Unstimulated BLP 0 5 10 15 20 25 0 50 75 100 ng hST2 (ng) Fold of stimulation Overexpression of ST2 inhibits MyD88-induced NF-?B activation 0