2型糖尿病患者血浆Apelin12水平与高血压胰岛素抵抗的相关（论文范文）.docVIP

2型糖尿病患者血浆Apelin12水平与高血压胰岛素抵抗的相关（论文范文） 文档信息 主题： 关于“论文”中“医学论文”的参考范文。 属性： F-00BPXA，doc格式，正文6436字。质优实惠，欢迎下载！ 适用： 作为医学论文、药学写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 作者： lunwenchina 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 搞要 1 关键字：Apelin?12;TNF?α;2型糖尿病;高血压;胰岛素抵抗 2 1 对象与方法 3 2 结 果 4 3 讨 论 5 【参考文献】 7 论文原创声明（模板） 8 论文致谢（模板） 9 正文 2型糖尿病患者血浆Apelin12水平与高血压胰岛素抵抗的相关（论文范文） 搞要 摘要：目的探讨Apelin?12与高血压、肥胖、胰岛素抵抗、炎症等的相关性。方法测定31例单纯2型糖尿病、37例2型糖尿病合并高血压患者及25例健康对照者血浆Apelin?12、肿瘤坏死因子α(TNF?α)、血脂、糖化血红蛋白(HbA1c)、空腹血糖、空腹胰岛素(FINS)、胰岛素抵抗(IR)指数(HOMA?IR)、体重指数(BMI)、血压等水平并进行各参数之间的相关分析。结果①糖尿病合并高血压组血浆Apelin?12水平低于正常对照组和单纯糖尿病组(P或P),单纯糖尿病组血浆Apelin?12水平高于正常对照组(P)。②糖尿病合并高血压组TNF?α水平高于糖尿病组和正常对照组(P或P)，糖尿病组TNF?α水平高于正常对照组(P)③直线相关分析显示，空腹血浆Apelin?12与腰臀比(WHR),FINS，HOMA?IR，甘油三酯(TG),收缩压(SBP)，TNF?α呈负相关,与HDL?C呈正相关。结论血浆Apelin?12水平在糖尿病组升高，在糖尿病合并高血压组降低，且与肥胖、IR、炎症等相关。推测Apelin?12可能参与了IR、2型糖尿病、高血压等疾病的发生发展 关键字：Apelin?12;TNF?α;2型糖尿病;高血压;胰岛素抵抗 【Abstract】 Objective To investigate the relationship between plasma apelin?12 level and hypertension, obesity, insulin resistance(IR), inflammation of type 2 diabetes mellitus(T2DM). Methods 25 healthy subjects of control group, 30 T2DM patients, 38 patients with T2DM and hypertension were selected. The plasma levels of apelin?12, tumor necrosis factor?α(TNF?α), blood fat, glycosylated hemoglobin(HbA1c), fasting plasma glucose, fasting insulin level, IR index(HOMA?IR), body mass index(BMI) and blood pressure were measured in each group. Data were analyzed by variable correlation. Results ① The apelin?12 levels in patients with T2DM and hypertension were significantly lower than that in control and T2DM groups(P or P),the apelin?12 level of patients with T2DM group was higher than that in control group (P).②TNF?α levels in patients with T2DM and hypertension was significantly higher than that in control and T2DM groups(P or P),TNF?α level of patients with T2DM only was significantly higher than that in control group(P).③There were negative correlation between the plasma ap