肺源性心脏病患者血浆C型利钠肽肾上腺髓质素的变化及意义医学.docVIP

肺源性心脏病患者血浆C型利钠肽肾上腺髓质素的变化及意义医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：肺源性心脏病患者血浆C型利钠肽肾上腺髓质素的变化及意义医学 1 1 对象与方法 3 2 结果 3 3 讨论 4 文2：浅谈原发性高血压患者血清C型利钠肽的变化及临床意义 5 1 材料与方法 7 2 结果 7 3 讨论 7 参考文摘引言： 8 原创性声明（模板） 10 文章致谢（模板） 10 正文 肺源性心脏病患者血浆C型利钠肽肾上腺髓质素的变化及意义医学 文1：肺源性心脏病患者血浆C型利钠肽肾上腺髓质素的变化及意义医学 Changes of plasma c-type natriuretic peptide and plasma adrenomedullin in patients with chronic pulmonary heart disease 【Abstract】 Objective To explore the role and clinical significance of plasma c-type natriuretic peptide (CNP) and adrenomedullin (ADM) levels in patients with chronic pulmonary heart Patients with chronic pulmonary heart disease in hospital, including acute exacerbation stage or clinical alleviated stage totally 100 cases, were participated in the study as experiment group. Meanwhile, 60 cases healthy peo were served as control group. Plasma CNP and ADM were measured by radioimmoassay and compared in the two groups, oxygen partial pressure and carbon dioxide partial pressure were measured at the same (1) the levels of plasma CNP and ADM in urgent aggravation stage of experiment group and clinical alleviation stage all were higher than the control group (P＜）；(2) the levels of plasma CNP and ADM in experiment group were higher than in control group significantly(r= -, -,P＜)；(3) the levels of plasma CNP and ADM in patients with chronic pulmonary heart were negatively correlated with oxygen partial pressure but no relatiohip with carbon dioxide partial pressure(r=,,P＞)；(4) The levels of plasma CNP was positively correlated with ADM(r=, P＜).Conclusion The plasma CNP and ADM were participated in the pathosphysiology process of pulmonary heart disease and reflected patient’s condition. 【Key words】 C-type natriuretic peptide; adrenomedullin; pulmonary heart disease(cor pulmonal) 肺动脉高压的形成是慢性肺源性心脏病的主要发病机制之一, 而肺血管阻力增加及肺动脉血管的结构重塑又是产生肺动脉高压的主要原因。笔者在慢性肺源性心脏病急性加重期和临床缓解期中检测了血浆C型利钠肽(c-type natriuretic peptide,CNP)、肾上腺髓质素(ADM)水平,探讨二者在肺动脉高压形成过程中的作用。 1 对