多发性骨髓瘤的精确诊断PPT课件.ppt

SMM with M protein 30g, and 10% PCs *Increase in serum monoclonal protein by ≥10% on each of two successive evaluations within a 6-month period. * * - * k * * * Clonal BM PC≥10% or biopsy proven bony or extramedullary plasmacytoma and ? ANY ONE OR MORE OF THE FOLLOWING MYELOMA DEFINING EVENTS (MDE) ? End organ damage (CRAB) that attributed to the PC disorder, Hypercalcemia: 11 mg/dL Renal insufficiency: Cr Cl 40 ml/minute or Serum Cr 2 mg/dL Anemia: Hb value 10 g/dL or 2 g/dL below the lower limit of normal Bone lesions: one or more osteolytic lesions on skeletal radiography, CT,