持续性静静脉血液滤过防治犬海水型呼吸窘迫综合征的实验研究临床医学.docVIP

持续性静静脉血液滤过防治犬海水型呼吸窘迫综合征的实验研究临床医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：持续性静静脉血液滤过防治犬海水型呼吸窘迫综合征的实验研究临床医学 1 1材料和方法 3 11动物准备 3 1．2动物制备及有关参数测定 3 13治疗方法 4 14统计学方法 4 文2：同种异体犬单肺移植的实验研究 7 1 材料与方法 8 2 结果 11 3 讨论 11 参考文摘引言： 13 原创性声明（模板） 15 文章致谢（模板） 15 正文 持续性静静脉血液滤过防治犬海水型呼吸窘迫综合征的实验研究临床医学 文1：持续性静静脉血液滤过防治犬海水型呼吸窘迫综合征的实验研究临床医学 Abstract： ObjectiveTo study the experimental canine models of respiratory distress syndrome (RDS) induced by immeion in seawater (SW) (SWRDS) and treated with continuous blood purification (CBP). MethodsHybrid dog SWRDS models were randomly assigned into trial group with continuous venoustovenous hemofiltration (CVVH) (n=7) and control group (n=7). Fifteen minutes after immeion in SW, the dogs in the trial group were purely removed 50-100 ml fluid during four hou’ CVVH treatment. The changes in blood gas analysis, endothelin (ET) and oxyradical were compared between the two groups, as well as the histological changes in the lung the dogs in the trial group survived, however two dogs in the control group died after four hou’ immeion in seawater. Fifteen minutes after immeion, blood gas analysis reported markedly metabolic acidosis, hypoxemia and decrease in the arterial pH, oxygen partial pressure (PaO2), saturation of blood oxygen (SO2), actual bicarbonate (AB) and base excess (BE). Afer four hou’ immeion, nitrogen monoxide (NO) and superoxide dismutase (SOD) decreased, whereas ET and malondialdehyde (MDA) with that of the control group, pH, AB and BE of the trial group were retrieved roughly to normal after four hou’ CVVH, PaO2 and SO2 ascended (not retrieved to normal), ET and MDA significantly decreased, and SOD ascended notably. In the trial group, lung histological changes including the shape and the findings under light microscope and electron microscope were significantly lessened when compared with that in the control CBP treatment for SWRDS dogs can retrieve acidbase balance, ameliorate hypo