乌司他丁对急性肺损伤患者血小板活化因子表达的影响.docVIP

乌司他丁对急性肺损伤患者血小板活化因子表达的影响 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：乌司他丁对急性肺损伤患者血小板活化因子表达的影响 1 1 临床资料 2 2 结果 4 3 讨论 4 文2：乌司他丁对心脏瓣膜置换术患者炎性因子的影响 6 1 资料与方法 7 2 结 果 9 3 讨 论 10 参考文摘引言： 12 原创性声明（模板） 13 文章致谢（模板） 14 正文 乌司他丁对急性肺损伤患者血小板活化因子表达的影响 文1：乌司他丁对急性肺损伤患者血小板活化因子表达的影响 【Abstract】Objective To investigate the expression of platelet-activating factor (PAF) in serum of acute lung injury patients (ALI) and the effects of ulinastatin on PAF expression and clinical symptom. Methods 37 patients of ALI were randomly divided into two groups, control and treatment groups. The vital sig and clinical symptoms were assessed before treatment and 5 days after treatment, respectively. Serum PAF level and blood gas analysis were also measured . Results Compared with those before treatment, the clinical symptom and blood gas analysis were improved and PAF level decreased in both groups These changes were more significant in treatment group（P or P）. The respiration support duration was significantly shortened in treatment group（P）. However, the case fatality ratio between two groups had no significant difference（P）. Conclusio Ulinastatin could decrease the expression of sera PAF in ALI patients as a non-specific PAF inhibitor. It could also relieve symptom of ALI, shorten the coue of disease. So, it could be a new approach for early clinical treatment of ALI. 【Key words】Acute lung injury(ALI) Platelet-activating factor Ulinastatin 急性肺损伤（acute lung injury，ALI）是由心源性以外的各种原因引起的严重肺部炎性反应，临床上以呼吸窘迫和顽固性低氧血症为主要特点。炎性介质的过度释放在ALI的发生 发展 过程中起着重要作用。血小板活化因子（platelet-activating factor，PAF）是一种重要的内源性磷脂类炎性介质，是迄今为止所发现的最强的血小板聚集诱导剂，在ALI的发生发展过程中起着重要的作用。本文旨在研究探讨ALI患者血清中PAF的表达，以及乌司他丁（ulinastatin，UTI）对PAF表达和临床症状的影响。 1 临床资料 研究对象 2005年6月至2006年3月，本院收治ALI 37例，均符合中华医学会呼吸病学分会制订的ALI诊断标准［１］，其中男29例，女8例，年龄17～73岁(平均岁)。原发病：呼吸道感染15例，严重外伤11例，严重烧伤3例，急性胰腺炎、败血症、海洛因中毒各2例，溺水和毒气吸入各1例。随机分为两组：对照组18例，治疗组19例。两组患者在性别、年龄及原发病构成上无统计学差别(P)，具可比性。 方法 对照组予以治疗原发病、抗感染、维持水电解质及酸碱平衡、使用激素、呼吸循环支持等常规治疗。治疗组在常规治疗的基础上，加用UTI（商品名天普洛