三七总苷对应激大鼠胃黏膜损伤及胃壁细胞超微结构的影响药学.docVIP

三七总苷对应激大鼠胃黏膜损伤及胃壁细胞超微结构的影响药学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：三七总苷对应激大鼠胃黏膜损伤及胃壁细胞超微结构的影响药学 1 1 器材 3 2 方法 3 3 结果 5 4 讨论 7 文2：褪黑素对枪击噪音应激大鼠胃黏膜损伤的影响及机制 8 1材料和方法 9 参考文摘引言： 12 原创性声明（模板） 14 文章致谢（模板） 14 正文 三七总苷对应激大鼠胃黏膜损伤及胃壁细胞超微结构的影响药学 文1：三七总苷对应激大鼠胃黏膜损伤及胃壁细胞超微结构的影响药学 Abstract：ObjectiveTo observe the effect of total saponi of Panax notogeng (P) on gastric mucosal lesion and ultrastructure of gastric mucosal parietal cells of stress rats. MethodsWater-immeion restraint stress (W)was used to induce rat models of stress. Six hou after W, the rats were executed to obtain the gastric tissue. The erosion and hemorrhage of gastric mucosa in rats were observed by naked eyes, and then the ulceration index (UI) was calculated. The ultrastructure of gastric mucosal parietal cells in rats was observed under tramission electron microscope. ResultsThe results observed by naked eyes showed that no lesion was found in the normal group. However, in the model group, the gastric mucosal congestion was obvious, there existed scattered punctiform erosion and bleeding in the glandular stomach, and the UI was ±; compared with the model group, gastric mucosal congestion was reduced and UI decreased in the P group and ranitidine group (P). Under the electron microscope, there were less endocrine tubular villi in the parietal cells of the normal group, showing a static status. However, in the model group, the number of endocrine tubular villi increased, showing an activating status; compared with the model group, the expaion of endocrine tubular villi was not obvious but the number of cytoplasm interior vesicles in parietal cells increased in P group, and in ranitidine group, the number of endocrine tubular villi was decreased and the number of vesicular structure was can reduce the stress-induced gastric mucosal lesion, and promote the wall cells of gastric mucosa traforming from the activated status into static status. The protective mechanism of P is probably