基质金属蛋白酶7和组织型金属蛋白酶抑制因子1在膀胱移行细胞癌中的表达及意义临床医学.docVIP

基质金属蛋白酶7和组织型金属蛋白酶抑制因子1在膀胱移行细胞癌中的表达及意义临床医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：基质金属蛋白酶7和组织型金属蛋白酶抑制因子1在膀胱移行细胞癌中的表达及意义临床医学 1 1 材料与方法 3 2 结果 4 3 讨论 5 文2：基质金属蛋白酶14和细胞外基质金属蛋白酶诱导因子在视网膜母细胞瘤中的表达及意义临床医学 7 1 资料与方法 8 2 结 果 9 3 讨 论 10 参考文摘引言： 12 原创性声明（模板） 14 文章致谢（模板） 15 正文 基质金属蛋白酶7和组织型金属蛋白酶抑制因子1在膀胱移行细胞癌中的表达及意义临床医学 文1：基质金属蛋白酶7和组织型金属蛋白酶抑制因子1在膀胱移行细胞癌中的表达及意义临床医学 ［Abstract］ Objective To evaluate the expression of matrix metalloproteinase-7（ MMP-7）and tissue inhibitor of matrix metalloproteinase-1（TIMP-1）in traitional cell carcinoma of bladder（TCCB）and its Immunohistochemistry was used to detect the expression of MMP-7 and TIMP-1 in 60 cases of BTCC（Grade Ⅰin 25 cases，Grade Ⅱ in 15，Grade Ⅲ in 20）and 5 subjects with normal bladder the 60 cases 29 had superficial（≤pT1）bladder cancer and 31 had invasive（≥pT2）bladder cancer.χ2 test was used to assess the relatiohip between expression of MMP-7，TIMP-1 and tumor grade， The expression of MMP-7 and TIMP-1 were negative in all normal bladder tissues but high in the 60 cases，40 were positive and 20 were negative for positivity was correlated with high histogical grade，but no significant difference was observed between superficial bladder cancer and invasive bladder were positive and 28 were negative for was no significant difference in different pathological grades or different clinical the ratio of MMP-7/TIMP-1 was correlated with high histogical MMP-7 and the ratio of MMP-7/TIMP-1 could reflect more accurately the malignant degree of results would provide a new significant marker in estimate of prognosis in patients with BTCC. ［Key words］ bladder neoplasmas;carcinoma;matrix metalloproteinases;tissue inhibitor of matrix metalloproteinases 基质金属蛋白酶是人体内降解细胞外基质（extracellular matrix，ECM）的主要酶类，在肿瘤演进等众多生理和病理过程中均发挥重要的作用［1］。MMP-7是MMPs家族中的主要成员之一，与多种肿瘤的恶性生物学表现以及预后密切相关。金属蛋白酶组织抑制因子（TIMPs）通过下调MMPs的活性及分泌，而抑制肿瘤的浸润和转移［2］。我们采用免疫组化方法检测60例膀胱移行细胞癌组织标本中MMP-7和TIMP-1的表达，探讨 MMP-7 、TIMP-1表达在膀胱移行细胞癌发生 发展 中的意义。 1 材料与方法 组织标本