玉竹多糖对四氧嘧啶糖尿病大鼠胰岛β细胞损伤的保护作用药学.docVIP

玉竹多糖对四氧嘧啶糖尿病大鼠胰岛β细胞损伤的保护作用药学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：玉竹多糖对四氧嘧啶糖尿病大鼠胰岛β细胞损伤的保护作用药学 1 1 材料与仪器 3 2 方法 3 3 结果 5 4 讨论 6 文2：芒果苷对糖尿病大鼠心肌损伤的保护作用 8 1.糖尿病心肌病大鼠模型 10 2. AP-1/TGF-β1/FN信号通路与糖尿病心肌病 11 三、芒果苷对糖尿病心肌的保护作用 12 1.　DCM的发病机制 14 参考文摘引言： 16 原创性声明（模板） 18 文章致谢（模板） 18 正文 玉竹多糖对四氧嘧啶糖尿病大鼠胰岛β细胞损伤的保护作用药学 文1：玉竹多糖对四氧嘧啶糖尿病大鼠胰岛β细胞损伤的保护作用药学 Protective Effect of Polygonatum odoratum Polysaccharides on Pancreatic β-cell Damage in Alloxan-induced Diabetes in Rats Abstract：ObjectiveTo evaluate the possible protective effects and mechanism of Polygonatum odoratum polysaccharides(PoPs)agait β-cell damage in experimental alloxan-induced diabetes in was injected intraperitoneally at a single dose of 180mg kg-1 for induction of oral administration with PoPs30 coecutive days for，the level of body weight,the fasting blood glucose（FBG）, I in serum and malondialdehyde(MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase(CAT)contents in pancreatic homogenates were assayed by samples were stained with hematoxylin-eosin (HE) and examined under a light successfully induced experimental diabetes in rats，pancreatic island significantly damaged by oxidative with PoPs markedly increased body weight，decreased fasting blood glucose levels；Furthermore, PoPs significantly blocked the increase of MDA production and increased SOD，GSH-Px，CAT activity in pancreatic homogenates in a dose dependent manner as compared wiht the diabetic control(P＜).Histopathological showed that the size and cell number of islets were reduced in diabetic control group and PoPs restored the damage of pancreas tissues in rats with diabetes mellitus. But PoPs had no significant influence on I in has protective effect on pancreatic β-cell damage and the mecharulm may be related wiht hypoglycemic effect and reduction of oxidative stress in alloxan-induced diabetes in rats. Key words：PoPs； Diabetes； Alloxan； Pancreatic β-cell； Oxidative stress 玉竹Polygonatum o