兔胸部爆炸伤后血液高凝状态的实验研究.docVIP

兔胸部爆炸伤后血液高凝状态的实验研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：兔胸部爆炸伤后血液高凝状态的实验研究 1 1 实验动物及分组 3 2 动物模型建立 3 3 监测指标和方法 3 4 统计处理 4 1 血液流变学变化 4 2 RLW变化 5 3 肺组织病 理学 变化 5 文2：兔椎间失稳软骨终板退变的实验研究 8 1 材料与方法 10 2 实验结果 12 3 讨论 12 参考文摘引言： 14 原创性声明（模板） 15 文章致谢（模板） 16 正文 兔胸部爆炸伤后血液高凝状态的实验研究 文1：兔胸部爆炸伤后血液高凝状态的实验研究 Abstract： Objective To investigate the changes of hemorrheologic characteristics and discuss blood hypercoagulability and its significance for pulmonary function in rabbits following explosive injury of Rabbits were subjected to chest explosive were randomly divided into control group and injury injury group was further divided into five groups according to the duration time after characteristics was examined by viscometer histologic changes of the lung were examined at 1/12,,1,3,6 hou after Five minutes after explosive injury,the whole blood viscosity,the plasma viscosity,the index of erythrocyte aggregation,plasma fibrinogen content and the index of erythrocyte deformability decreased compared with the control group,but increased after 30 minutes and reached maximum at 3 hou after injury(P).The whole blood viscosity,the plasma viscosity,the index of erythrocyte aggregation and plasma fibrinogen content were lower 6 hou after injury but still higher than that of control group(P).Hemorrheologic characteristics was correlated with the severity of lung The hemorrheologic characteristics change significantly after explosive injury of chest,and blood hypercoagulability may cause damage to microcirculation and lead to dysfuntion of one or more orga,even MSOF. Key words：explosive injury;chest injury;hypercoagulability;microcirculation 各种应激状态后血液流变学常发生变化，从而造成血凝状态的异常改变，常与脏器功能障碍密切相关[1]。但关于胸部爆炸伤后血液血凝状态的变化报道甚少。我们通过兔胸部爆炸伤模型，探讨致伤后早期血液流变特性的变化规律及其对微循环及肺脏等器官的影响,为临床早期妥善处理提供理论依据。 材料与方法 1 实验动物及分组 健康中国家兔(军事医学 科学 院实验动物中心提供)48只，雌雄不限，体重(±)kg，随机分为对照组(1组)和爆炸伤后5、30分钟、1、3、6小时5个致伤组(2～6组)，每组8只。 2 动物模型建立 伤前禁食12小时，耳缘静脉静注3%戊巴比妥钠1ml/kg体重麻醉，参照我们预实验结果，将兔固定于致伤架上，左