前列地尔脂微球载体注射液对老年下肢动脉血管病变患者血小板活化功能的影响临床医学.docVIP

前列地尔脂微球载体注射液对老年下肢动脉血管病变患者血小板活化功能的影响临床医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：前列地尔脂微球载体注射液对老年下肢动脉血管病变患者血小板活化功能的影响临床医学 1 1 对象与方法 3 2 结果 4 3 讨论 5 文2：观察缬沙坦胶囊联合前列地尔脂微球载体制剂对 7 1 资料与方法 7 2 结果 8 3 讨论 8 4 参考文献 9 参考文摘引言： 9 原创性声明（模板） 10 文章致谢（模板） 11 正文 前列地尔脂微球载体注射液对老年下肢动脉血管病变患者血小板活化功能的影响临床医学 文1：前列地尔脂微球载体注射液对老年下肢动脉血管病变患者血小板活化功能的影响临床医学 【Abstract】 Objective To assess the infection of Liposomal prostaglandin E1 (LipoPGE1) on hematoblastic activation function with lower limb arterial blood vessel disease in geriatrics. Methods 120 patients with lower limb blood arterial vessel disease were randomly divided into control and treatment groups. Patients in treatment group were administered with LipoPGE1 (20 μg/d) for 14 days, patients in control group were administered with Ginkgo Biloba Leaf Extract (70 mg/d) for 14 days. Clinical symptom was observed, vascular diameter and blood flow velocity of femoral artery, popliteal artery, posterior tibial artery and doal pedal artery were evaluated by Doppler uitrasonography examination, blood glucose level, blood lipid level, peptase, renal function, αgranule membrane protein (GMP140), hematoblastic CD62p and CD63, 6ketoneprostacyclin(6kPGF1α), thromboxane B2(TXB2) were measured pre and post treatment. Results After given LipoPGE1 post treatment, the clinical symptoms and sig had been mended in the patients with lower limb arterial blood vessel disease, vascular diameter and blood flow velocity of femoral artery, popliteal artery, posterior tibial artery and doal pedal artery were increased, however, there were no significantly differences. GMP140, CD62p, CD63, 6kPGF1α,TXB2 were decreased, and there were significant differences between control and treatment groups (P＜). The other indicato did not change, there were no significant differences (P). Conclusio LipoPGE1 can inhibite hematoblastic activation function, improve the symptom with lower limb arterial blood vessel disease, which is sa