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当归注射液对大鼠实验性弥散性血管内凝血血液动力学的影响
目录
TOC \o 1-9 \h \z \u 目录 1
正文 1
文1:当归注射液对大鼠实验性弥散性血管内凝血血液动力学的影响 1
1 材料和方法 3
2 结果 4
3 讨论 5
文2:夏至草醇提物对实验性弥散性血管内凝血大鼠心肌损伤的影响 6
1 材料和方法 8
2 结果 9
3 讨论 10
参考文摘引言: 11
原创性声明(模板) 12
文章致谢(模板) 13
正文
当归注射液对大鼠实验性弥散性血管内凝血血液动力学的影响
文1:当归注射液对大鼠实验性弥散性血管内凝血血液动力学的影响
Abstract:ObjectiveTo explore the effects of Angelica parenteral Injection (APS) on hemodynamics in rats with disseminated intravascular coagulation(DIC). MethodsA model of DIC was made in rats by Dextran500 injection from jugular vein, and effects of APS on micro-vessels, micro- area blood flow volume of orga, blood viscosity and platelet aggregation were studied in rats by an observation of mesenteric microcirculation, determination of hemorheology and blood flow microcirculation disturbance was mainly micro-vessels contraction, slow micro-blood flow and micro-thrombus after Dextran 500 injection. The result showed that APS could dilate micro-vessel obviously and reduce multiple score values of blood flow and blood cell aggregation, there were obvious differences compared with normal saline () group (P). The micro-area blood flow volume of stomach, intestine and liver was evidently increased in APS and groups, however, the former effect was superior to group (P). After treatment with APS, the blood viscosity and platelet aggregation were obviously lower than those of group, and meantime the deformity ability of RBC was obviously increased (P). ConclusionAPS can influence the recovery of DIC through dilating micro-vessel, increasing blood flow volume of orga, and reducing blood viscosity and platelet aggregation.
Key words:Angelica parenteral Injection;DIC;Microcirculation; Blood flow volume; Hemorheology
当归有补血治淤、调经止痛、润肠通便的功效,是临床常用中药之一。研究表明[1],当归可减少氧自由基产生,增强SOD活性,保护受损的血管内皮细胞,具有抗炎及双向免疫调节的作用。为了进一步了解当归对疾病的治疗作用基础,本研究从微循环、血液流变学、器官血流量等角度,探讨当归对大鼠弥散性血管内凝血(disseminated intravascular coagulation,DIC)血液动力学的影响。
1 材料和方法
材料
Wistar雄性大鼠, 中国 医科院实验动物繁育中心提供;当归注射液(Angelica
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