生物信息学概论的案例2.pptVIP

Science 296: 340 4/12/2019 Science 2019/1/29 (express online) The Galapagos Finches （达尔文雀） 鸟喙与人类工具 美国普林斯顿大学格兰特教授夫妇 四种典型达尔文雀的喙 同义置换与非同义置换 同义: Sequence 1: UUU CAU CGU Sequence 2: UUU CAC CGU Coded Amino Acids: Phe His Arg 非同义: Sequence 1: UUU CAU CGU Sequence 2: UUU CAG CGU Coded Amino Acids: Phe His Arg Gln KA: nonsynonymous substitution (非同义置换) KS: synonymous substitution (同义置换) 1 Positive selection (正选择) KA / KS =1 Neutral evolution (中性进化) 1 Negative selection