理论有机化学第八章消除反应Elemination.pptVIP

Competition between substitution and elimination Substrate Weak base Weak nucleophile EtOH,MeOH,H2O Weak base Good nucleophile I-,CH3COO-, N3-. CN-, RS-. Strong base, Good nucleophile, OH-,MeO-,EtO-, Strong bulky base ,no good nucleophile (CH3)3CO-. CH3X No reaction 1°RX No reaction 1°RX (Branched) No reaction 2°RX 3°RX Competition between substitution and elimination Substrate Weak base Weak nucleophile EtOH,MeOH,H2O Weak base Good nucleophile I-,CH3COO-, N3-. CN-, RS-. Strong base, Good nucleophile, OH-,MeO-,EtO-, Strong bulky base ,no good nucleophile (CH3)3CO-. CH3X No reaction