抗菌治疗进展.pptVIP

* Trough serum vancomycin concentrations always be maintained at 10 mg/L to avoid the development of resistance (BIII) To improve clinical outcomes of hospital-acquired pneumonia caused by S. aureus, trough serum vancomycin concentrations of 15–20 mg/L are recommended (Note: much higher than former concentration of 5-10 mg/L) (BIII) To achieve rapid attainment of this target concentration for seriously ill patients, a loading dose of 25–30 mg/kg )(1.5-1.8 g)(based on actual body weight) can be considered. (BIII Trough serum vancomycin concentrations in that range should achieve an AUC/MIC of 4