大蒜素保留灌肠治疗溃疡性结肠炎临床研究.docVIP

大蒜素保留灌肠治疗溃疡性结肠炎临床研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：大蒜素保留灌肠治疗溃疡性结肠炎临床研究 1 1 对象与方法 2 2 结果 3 3 讨论 4 文2：康复新液保留灌肠治疗溃疡性结肠炎的临床研究 5 1资料与方法 5 2 结果 6 2组疗效比较 见表1。 6 3 讨论 6 参考文摘引言： 7 原创性声明（模板） 9 文章致谢（模板） 9 正文 大蒜素保留灌肠治疗溃疡性结肠炎临床研究 文1：大蒜素保留灌肠治疗溃疡性结肠炎临床研究 Abstract： Objective To investigate the clinical efficacy of garlicin retention enema on the patientse with ulcerative colitis， as well as the advee effect and the halfyear relapse. Methods Ninety patients with ulcerative colitis were pided into trial group (n=50) and control group (n=40) at random. The patients in the trial group were treated by retention enema with garlicin (40 mg) once per night， while the patients in the control group were treated by 1 g of salicylazesulfapyridine four times a day and 200 mg of glutathione thrice a day. The treatment coue lasted for one month for both the groups. After one month and six months， examination was done， including hepatic function and endoscopy， and the incidence of advee events was The total effective rates were % in the trial group and % in the control group， while their half year relapse rates were % and %， respectively. There were significant differnces between the two groups (P). Conclusion Garlicin has a good treatment effect on ulcerative colitis without obviously advee effect. Key words： garlicin; retention enema; ulcerative colitis; salicylazesulfapyridine 溃疡性结肠炎(UC)为一种慢性反复发作，较为难治的炎症性肠病，其发病原因迄今尚未明确，目前一般认为主要与炎症介质、免疫及遗传等因素有关。临床上尚无特效药，治疗该病的主要药物包括水杨酸制剂和皮质激素及免疫制剂等，但均存在疗效不满意、副作用大及复发率高等缺点。我院于2006年6月始采用大蒜素治疗溃疡性结肠炎取得较好疗效，现报告如下。 1 对象与方法 对象 本组90例患者均符合2000年全国炎症性肠病学术会议修改的UC诊断标准(成都)[1]。系本院门诊及住院患者，并自愿签署接受一个疗程的治疗及治疗后复查和随访半年的协议，病程半年～14年，平均为（6±）年。临床表现为持续或反复发作的腹泻、黏液脓血便、腹痛及里急后重等。2次以上大便培养未发现致病菌。结肠镜检查:肠黏膜轻、中度充血，水肿，多发性溃疡，血管纹理不清。90例患者中腹泻者76例( %)，黏液脓血便53例( %)，腹痛48例(%)，里急后重者34例(%)。随机将患者分为两组:治疗组50例，男36例，女14例，年龄25～52岁，平均（±）岁， 腹泻42例，黏液脓血便29例，腹痛26例，里急后重19例；轻度患者9例，中度患者34例，重度患者7例。对照组40例，男26例，女14例，年龄19～62岁，平均（±）岁，腹泻34例，黏液脓血便24例，腹痛22例，里急后重15例；轻度患者12例