宫颈癌患者外周血淋巴细胞亚群分布的差异分析.docVIP

宫颈癌患者外周血淋巴细胞亚群分布的差异分析 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：宫颈癌患者外周血淋巴细胞亚群分布的差异分析 1 1 资料与方法 3 2 结果 5 3 讨论 7 文2：中晚期肝癌患者外周血淋巴细胞亚群的研究 9 1 材料与方法 9 2 结果 12 3 讨论 13 参考文摘引言： 14 原创性声明（模板） 16 文章致谢（模板） 16 正文 宫颈癌患者外周血淋巴细胞亚群分布的差异分析 文1：宫颈癌患者外周血淋巴细胞亚群分布的差异分析 Analysis of the differences of distribution of lymphocyte subsets in peripheral blood in the patients with cervical cancer YU Hong1 ZHANG Gengyue1 JIN Yulong1 DI Na1 HE Chunying1 WEI Tianxue1 DU Renqiu2 Biology Research Office， Jilin Research Center for Tumor Prevention and Control， Changchun 130012， China； Record Room， Jilin Tumor Hospital， Changchun 130012， China [Abstract] Objective To test and analyze the differences of distribution of lymphocyte subsets in peripheral blood in the patients with cervical cancer and its clinical significance. Methods Percentages of CD3+， CD3+CD4+， CD3+CD8+， NK， NKT， CD8+CD28+， CD8+CD28-， CD3+HLA-DR+， CD3-HLA-DR+， Treg cells were tested in adult peripheral blood in the patients with cervical cancer and health controls via flow cytometry. Comparative analysis was conducted in combination with the clinical diagnosis staging in the patients with cervical cancer. Results Compared with the healthy control group， the percentages of CD3+（P=） and CD3+CD4+ T cells（P=） in the peripheral blood in the patients with cervical cancer and CD3+CD4+/CD3+CD8+ ratio（P=） were significantly reduced； the percentages of CD3+CD8+ T cells in the patients with cervical cancer were not statistically significant compared with that in the control group， but with the increase of clinical staging， the percentage was in a decreasing trend（P=）. The percentages of NK cells （P）， activated T cells （CD3+HLA-DR+：P）， and activated B cells （CD3-HLA-DR+： P=） were significantly improved； the percentage of toxic T cells （CD8+CD28+） was reduced （P=）， and the percentage of inhibitive T cells（CD8+CD28-） was increased（P=）； the percentage of CD4+CD25bright （Treg） cells was not significantly different fr