干扰素治疗对慢性乙肝患者CD4CD25调节性T细胞水平的影响研究.docVIP

干扰素治疗对慢性乙肝患者CD4CD25调节性T细胞水平的影响研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：干扰素治疗对慢性乙肝患者CD4CD25调节性T细胞水平的影响研究 1 1 资料与方法 3 2 结果 4 3 讨论 6 文2：CD4CD25调节性T细胞与头颈部肿瘤 7 3 TGFβ对CD4+ CD25+ Treg细胞的调节 8 4 VEGF对CD4+CD25+　Treg细胞的调节 10 参考文摘引言： 13 原创性声明（模板） 13 文章致谢（模板） 14 正文 干扰素治疗对慢性乙肝患者CD4CD25调节性T细胞水平的影响研究 文1：干扰素治疗对慢性乙肝患者CD4CD25调节性T细胞水平的影响研究 Effect of CD4+ CD25+ regulatory T cell level of chronic hepatitis B during interferon theraping XUE Haibo1 MA Lili2 LIN Xianfan1 WU Jinming1 Fit Department of Gastroenterology， the Fit Affiliated Hospital of Wenzhou Medical Univeity， Wenzhou 325000， China； of Rheumatology and Immunology， the Fit Affiliated Hospital of Wenzhou Medical Univeity， Wenzhou 325000， China [Abstract] Objective To investigate the changes and clinical significance of peripheral blood regulatory T cells in chronic hepatitis B patients treated with interferon. Methods 60 patients with chronic hepatitis B who were treated with interferon and 20 healthy adults were selected from January 2013 to January 2015 in our hospital. Peripheral blood was collected before treatment and 12th weeks， 24th weeks， 36th weeks， 48th weeks after treatment and 24 weeks after withdrawal， the changes of CD4+CD25+ regulatory T cells （Tregs）， serum HBV-DNA and glutamate pyruvate aminotraferase （ALT） in peripheral blood were compared. Results There were no significant differences in the proportion of CD4+CD25+ regulatory T cells， ALT content and HBV-DNA content between complete respoe group， partial respoe group and non respoe group before treatment（P）， but they were significantly higher than those in healthy control group， there were statistically significant differences between the groups（P）； The proportion of Tregs in the complete respoe group and the partial respoe group after treatment were significantly decreased compared with that before treatment（P）； The proportion of Tregs in patients of complete respoe group and partial respoe group had been declining during