高等有机化学教学课件电子教案全套课件一.pptx

Advanced Organic Chemistry ;March’s Advanced Organic Chemistry Reaction, Mechanism, and Structure 5th edition Michael B, Smith and Jerry March;;1. Bonding Weaker than Covalent; Hydrogen bonding Addition compounds Others;Hydrogen Bonding;;J. Am. Chem. Soc., 121 (17), 4280 -4281, 1999. ;282.4 MHz 19F NMR spectra of H(1) dissolved in methylcyclohexane-d14. Only the ortho-CF3 region is shown in both spectra. ;J. Am. Chem. Soc., 121 (17), 4280 -4281, 1999. ;;;;;Intermolecular hydrogen bonding raises boiling points and frequently melting points;Hydrogen bonding between solute and solvent greatly increase solubility and often results in large or even infinite solubility where none would otherwise be expected.;Hydrogen binding cause lack of ideality in gas and solution laws;Hydrogen bonding changes many chemical properties;J. Am. Chem. Soc.; 1999; 121(26); 6324-6325. ?;J. Am. Chem. Soc., 121 (23), 5607 -5608, 1999. ;J. Am. Chem. Soc., 121 (23), 5607 -5608, 1999. ;J. Am. Chem. Soc., 124 (16), 4287 -4297, 2002. ;J. Am. Chem. Soc., 124 (16), 4287 -4297, 2002. ;J. Am. Chem. Soc., 124 (16), 4287 -4297, 2002. ;;;;;Addition Compounds;Electron donor-acceptor complexes;;;;;acceptor;Addition compounds of picrate with some ethers/amines;Crown ether complexes and cryptates;;Org. Lett., 2004, 6, 3301-3303;J. Org. Chem. 2002, 67(19): 6632 - 6637 ;Org. Lett. 2002, 4(14): 2313 - 2316;Fluorescent, Sequence-Selective Peptide Detection by Synthetic Small Molecules? Chao-Tsen Chen, Holger Wagner, and W. Clark Still ? Science 1998, 279: 851-853.;absence of peptide; presence of 5?mM peptide P1, presence of 5?mM peptide P2.;;;Chromogenic Indoaniline Armed-Calix[4]azacrowns Jong Seung Kim,* Ok Jae Shon, Seung Hwan Yang, Jong Yeol Kim, and Moon Jib Kim J. Org. Chem., 67 (18), 6514 -6518, 2002. ;Chromogenic Indoaniline Armed-Calix[4]azacrowns Jong Seung Kim,* Ok Jae Shon, Seung Hwan Yang, Jong Yeol Kim, and Moon Jib Kim J. Org. Chem., 67 (18), 6514 -6518, 2002. ;Inclusion Compound