非外伤性结直肠穿孔早期死亡率的影响因素分析.docVIP

非外伤性结直肠穿孔早期死亡率的影响因素分析 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：非外伤性结直肠穿孔早期死亡率的影响因素分析 1 1 临床资料 3 2 结果 4 文2：非外伤性结直肠穿孔早期死亡率的影响因素分析 4 1 临床资料 6 2 结果 7 3 讨论 7 参考文摘引言： 9 原创性声明（模板） 11 文章致谢（模板） 11 正文 非外伤性结直肠穿孔早期死亡率的影响因素分析 文1：非外伤性结直肠穿孔早期死亡率的影响因素分析 Facto affecting the early mortality of patients with nontraumatic colorectal perforation 【Abstract】 Objective We attempted to identify the facto associated with the early mortality of patients with nontraumatic colorectal perforation.Methods 62 patients who underwent surgery for nontraumatic colorectal perforation between May 1994 and December 2002 were retrospectively reviewed.Age, sex, cause of perforation, duration of symptoms, associated preoperative septic shock, concomitant disorde (including cardiac disease, chronic obstructive pulmonary disease, hemodialysis, and steroid treatment), operative findings (such as the site of perforation and the degree of peritonitis), and results of preoperative laboratory blood tests (such as the white blood cell count and platelet count) were analyzed for their association with early outcome using univariate and multivariate analysis.Results 12 of the 62 patients died during hospitalization.According to the univariate analysis,advanced age, preoperative septic shock, concomitant disease, hemodialysis, diffuse peritonitis,and a low preoperative platelet count were more frequent in the patients who died during hospitalization.According to the logistic regression analysis, preoperative septic shock (odds ratio 8.443, 95% confidence interval (CI) 1.896-41.493), concomitant end-stage renal failure (odds ratio 12.567, 95% CI 1.598-109.531), and diffuse peritonitis (odds ratio 14.367, 95% CI 1.457-118.154) were the most significant facto related to in-hospital mortality.Conclusion Early diagnosis before the patient’s general condition deteriorates is a key to improving the early mortality associated with nontraumatic colorectal perforation, especially in patients with c