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AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-
randomised studies of healthcare interventions, or both
1. Did the research questions and inclusion criteria for the review include the components of PICO?
For Yes: Optional (recommended)
Population Timeframe for follow-up Yes
Intervention No
Comparator group
Outcome
2. Did the report of the review contain an explicit statement that the review methods were
established prior to the conduct of the review and did the report justify any significant deviations
from the protocol?
For Partial Yes: For Yes:
The authors state that they had a written As for partial yes, plus the protocol
protocol or guide that included ALL the should be registered and should also
following: have specified:
Yes
review question(s) a meta-analysis/synthesis plan, Partial Yes
a search strategy if appropriate, and No
inclusion/exclusion criteria a plan for investigating causes
of heterogeneity
a risk of bias assessment
justification for any deviations
from the protocol
3. Did the review authors explain their selection of the study designs for inclusion in the review?
For Yes, the review should satisfy ONE of the following:
Expla
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