T细胞亚群最好的漂亮免疫.pptxVIP

会计学1T细胞亚群最好的漂亮免疫 第1页/共53页 第2页/共53页 Classes of lymphocytes第3页/共53页 T 细胞亚群 T 细胞活化分子机制 T 细胞免疫应答及其效应 自身免疫和超敏反应第4页/共53页 T cell subsets ?? T cells and ?? T cells CD4+T cells and CD8+T Na?ve T cells（初始T细胞） Effector T cells （效应T细胞） Memory T cells （记忆T细胞） T helper (Th) 辅助性CD4+T细胞 Cytotoxic T cells (CTLs) 细胞毒性CD8+T细胞 Regulatory T cells (Tregs) 调节性CD4+T细胞第5页/共53页 T Cell subsetsClassFunctionsAntigen receptor and specificitySelected markersPercent of total lymphocytes (human)αβ T lymphocytes?BloodLymph nodeSpleen?CD4+ helper T lymphocytesB cell differentiation (humoral immunity)Macrophage activation (cell-mediated immunity)αβ heterodimersDiverse specificities for peptide-class II MHC complexesCD3+, CD4+, CD8-50-60*50-6050-60??CD8+ cytotoxic T lymphocytesKilling of cell infected with microbes, killing of tumor cellsαβ heterodimersDiverse specificities for peptide-class I MHC complexesCD3+, CD4-, CD8+20-2515-2010-15Regulatory T cellsSuppress function of other T cells (regulation of immune responses, maintenance of self-tolerance)αβ heterodimersCD3+, CD4+, CD25+ (Most common, but other phenotypes as well)Rare1010γδ T lymphocytesHelper and cytotoxic functions (innate immunity)γδ heterodimersLimited specificities for peptide and nonpeptide antigensCD3+, CD4, and CD8 variable???第6页/共53页 ?? T cells express a limited number of TCRs abundant in epithelial tissues of certain species: in the small bowel mucosa and in the skin of mouse. In the skin, known as a dendritic epidermal T cell (DETC) do not recognize MHC-associated peptide antigens and are not MHC restricted. may bind to conserved ligands whose expression is triggered by cell injury or stress, such as microbial heat shock proteins. may represent an important bridge between innate and adaptive immunity, functioning as lymphocytes that enhance the first line of defense against a range of pathogens. 第7页/共53页 Jensen, K. D. et al. Thymic selection determines ?? T cell effector fate: antigen-naive cells ma