(8.5.7)--StartingattheBeginning,Middle,an建筑设备工程.pdfVIP

Cell, Vol. 89, 831–838, June 13, 1997, Copyright 1997 by Cell Press Starting at the Beginning, Review Middle, and End: Translation Initiation in Eukaryotes Alan B. Sachs,* Peter Sarnow,† studies, which are covered in more detail below, these and Matthias W. Hentze‡ current models fail to fully explain this early stage of *Department of Molecular and Cell Biology translation initiation. This review will discuss recent find- University of California at Berkeley ings that implicate different ways by which the 40S small Berkeley, California 94720 ribosomal subunit can be recruited to eukaryotic mRNA † Department of Microbiology and Immunology and the various ways this recruitment step can be regu- Stanford University School of Medicine lated. It will then present an integrated model of the 40S Stanford, California 94305 subunit recruitment step. ‡ Gene Expression Programme European Molecular Biology Laboratory Starting at the Beginning: The Cap Structure Meyerhofstrasse 1 and 40S Subunit Recruitment D-69117 Heidelberg All eukaryotic mRNAs and many viral RNAs bear a 5 ter- Germany minal nuclear modification, the cap structure (7mGpppN). The cap integrates several important functions and af- fects RNA splicing, transport, stabi