复旦生物无机化学a.pptxVIP

会计学1复旦生物无机化学a Chapter 1 Introduction 1. What is Bioinorganic Chemistry? 2. Inorganic Elements in Biological Systems3. Biological Ligands (Biologically Important Compounds)4. Experimental Methods (Physicochemical Methods and Biological Methods)第1页/共12页 1.1 What is Bioinorganic Chemistry?1.1.1 Bioinorganic Chemistry is a leading discipline at the interface of chemistry and biologyMany critical processes require metal ions, including respiration, much of metabolism, nitrogen fixation, photosynthesis, development, nerve transmission, muscle contraction, signal transduction, and protection against toxic and mutagenic agents.Synthetic Chemists, Spectroscopists, Electrochemists, Theoreticians, Biochemists, and molecular Biologists meet at the frontiers of chemistry and biology and are challenged by exciting problems.第2页/共12页 1.1.2 Development of Bioinorganic Chemistry Molecule, Cell, and Humanity elements small molecules amino acids, nucleotides,carbohydrates, fatty acids protein(enzymes), lipids, poly-carbohydrates poly-nucleotides metalloproteins (metalloenzymes), other macromolecules procaryocyte, eucaryocyte bacteria, microorganisms, plants, animals, humanity 第3页/共12页 The first symposium on bioinorganic chemistry was initiated by inorganic chemists in 1970The first book called “ Bioinorganic Chemistry” was written by 45 authors and published in 1973第4页/共12页 1.1.3 Current Situation Inorganic Biochemistry: An Introduction James A. Cowan The Ohio State University 1993, 1997 Principles of Bioinorganic Chemistry Stephen J. Lippard Maqssachusett Institute of Technology Jeremy M. Berg John Hopkins School of Medicine第5页/共12页 The International Conference on Biological Inorganic Chemistry1983 in Florence, Italy1985 in the Algarve, Portugal1987 in Noordwijkerhout, The Netherlands1989 in Cambridge, USA1991 in Oxfor