达托霉素药理特性.pptxVIP

达托霉素药理特性一、达托霉素(Daptomycin)的杀菌特性环脂肽类抗生素Cyclic lipopeptide Streptomyces roseosporus 的天然發酵物分子式 C72H101N17O26分子量 1620、67無菌、無熱原淡黃色~淺棕色塊狀凍晶賦形劑為NaOH (調整pH值)Clinical Infectious Diseases?2004;38:994-1000Anti MRSA 比较 – 分类Brand NameCubicin ? Tygacil ? Zyvox ? Vancocin? Targocid ? DaptomycinTigecycline Linezolid VanycinTeicoplanin US Launch 2003200520001964noneClasscyclic lipopeptide glycylcycline oxazolidinoneglycopeptideglycopeptidecidal/staticrapidly cidal static staticslowly cidal slowly cidal Location of activityCell MembraneRibosomal subunitRibosomal RNA subunitCell WallCell WallDaptomycin达托霉素作用机制为