化学结构和药物代谢.pptxVIP

第1页/共184页化学结构和药物代谢第2页/共184页 Section 1 IntroductionThe physicochemical properties of drugs that predispose (使偏向于) them to good absorption, such as lipophilicity (亲脂性) , are impediment(妨碍) to their elimination. As a consequence, the elimination of drugs normally requires their conversion into water soluble compounds by a process of metabolism, which enables excretion via urine or faeces(排泄物). 第3页/共184页 Metabolism Metabolism is often the major factor defining the pharmacokinetics of drugs, which in turn can influence the efficacy and side-effect profile of these compounds. The chemical nature an