临床药理培训资料课件.pptVIP

In CAST, patients with VPCs and a recent myocardial infarction were randomly assigned to one of three sodium channel blocker therapies, which was then titrated to the dose that appeared to suppress VPCs on a 24-hour Holter monitor. Once the effective dose and drug were established, patients were randomly assigned to continue drug or placebo. Remarkably, mortality among patients randomized to drug was 2 to 3 times that among those randomized to placebo. 第三十一页，共五十二页。 The mechanism underlying this striking, and previously undefined, effect of sodium channel block remains uncertain. However,