伪狂犬病的控制和清除.pptxVIP

伪狂犬病的控制和清除;PSEUDORABIES Control and Eradication 伪狂犬病的控制和清除;Pseudorabies 伪狂犬病 PRV 伪狂犬病病毒 Aujeskys Disease (AD) 奥叶斯基病 Infectious Bulbar Paralysis 感染性延髓麻痹 Historical Records report disease in Cattle in early 1800s 早在1800年有报道该病发生于牛 All species of mammals susceptible. 哺乳动物易感 Cats, Dogs, Sheep, Cattle, Horses, Rats, Monkeys. Man is resistant. Rare reports in Humans (Skin rash). 人有抵抗性，人感染的报道很少见（皮疹） PRV was often confused with swine fever. 常与猪瘟相混 ;急性： 流产，木乃伊，死胎，不孕 腹泻，中枢神经症状 High mortality in small pigs 仔猪高死亡率 Pre-wean can be almost 100% 断奶前几乎100％ 5 - 9 weeks less than 10% 5－9周龄低于10％ Less than 2% in older pigs 稍大猪低于2％ Coughing, sneezing 咳嗽，喷嚏 Skin lesions/Itching (not common) 皮肤病变/痒（不多见） Varying pathogenicity, sometimes acute form not seen 病毒的致病性不同，有时未见急性型 ;慢性： Pneumonia in Grow-finish 生长肥育阶段肺炎 Immunity from sow lasts for up to 15 weeks, protective 6 to 12 weeks 母体免疫力可持续到 15 周龄，但保护性只到 6－12 周龄 Immunosuppression, Secondary Infection 免疫抑制，继发感染 APP, Strep, Mycoplasma Interactions Sow herd fairly stable, G/F is virus factory 母猪群很稳定，生长肥育猪产生病毒 Immunity can be cyclic in sow herd 母猪群免疫力可循环 ;Pseudorabies Spread 伪狂犬病的传播 Infected Pigs - 病猪 Lifetime Latent infection 潜伏感染 Virus Shedding when stressed 应激状态下产生病毒 Fomites 污染物 Trucks, Boots, Premises 卡车，靴子，环境 Aerosol 空气传播 Spreads 3 km very easily 很容易就能传播 3 公里 Circle/Area Vaccination Essential 环形/区域免疫是必需的 ;PRV - Route of Infection 感染途径 Intranasal/oral route 鼻腔/口腔途径 Nasal Epithelial cells 鼻腔上皮细胞 Nerve Cells - - - up nerves to CNS 神经细胞－－向上至中枢神经系统 Tonsil 扁桃体 Respiratory Tract 呼吸道 Lymphoid Tissues 淋巴组织 Semen/Uterine route possible 可能的精液/子宫途径;After Infection: 感染后 The Pig sheds virus for 10 to 14 days. 10－14天期间产生病毒 Virus becomes Latent in Nerve Tissue. 病毒在神经组织潜伏 Pig is infected for its Lifetime. 终生感染 Periodic recrudescence occurs. 周期性复发 Latent Infection is detectable by PCR. PCR技术可检测潜伏感染 ;Gross Lesions 总体病变 Sometimes No Gross Lesions are visible