二零二三年 优质公开课Generalidentificationtestofdrugs.pptxVIP

Pharmaceutical analysis General identification test of drugs General identification test of drugs ——Aromatic primary amines Author: (Shi Lei) General identification of drugs General identification test is to identify the authenticity of drugs through chemical reactions based on chemical structure, physical and chemicalproperties of a certain variety of drugs. Inorganic drugs are identified based on thecharacteristic reaction of anions and cations, while organic drugs are identified based on the functional group reaction of drugs. Therefore, the general identification test can only identify drug variety, but cannot accurately recognize a specific drug. Introduction of aromatic primary amine Aromatic amine drugs are mainly classified into two varieties: Benzocaine drugs in which aromatic primary amino is not substituted but there is substitution at the aromatic ring para-position. Acid amide drugs in which aromatic primary amino is acylated and there is substitution at the aromatic ring para-position. Aromatic amine Aromatic primary amino Key and difficult points Master UnderstandThe principle for pharmaceutical identification of aromatic primary amines Selection principle of pharThe methods for pharmaceutical identification of aromatic primary amines maceutical identification methods; UnderstandThe aromatic primary amino structure and potential aromatic primary amino structure of drugs 1. Identification principle The reaction of aromatic primary amine and nitrous acid to form diazonium salt is called diazotization. The diazotization reaction should be carried out in strong acid. It is in fact a process of nitrous acid acting on ammonium ions. Since nitrous acid is unstable, sodium nitrite and hydrochloric acid or sulfuric acid are usually used to make the nitrous acid produced by the reaction react with aromatic primary amine immediately to prevent the decomposition of nitrous acid. For normal reaction, aromatic primary amine must be converted into ammonium catio