牙周病与免疫.pptxVIP

牙周病与免疫; The oral cavity harbors more than 700 bacterial species, coexisting with probably millions of viral genomic copies. 口腔定居的细菌有700多种 与数百万病毒基因组复制物共存 （A Tsuo Amano, 2010, Periodontology 2000）;Oral bacteria 口腔中的细菌： -- Free to saliva 在唾液中 -- Attachment in biofilm 附着在生物膜 Between closely related;In United States, 75 per cent of adult populations suffer from periodontal disease. 美国占75%成年人群体不同程度患有牙周病 1/3 children of 6~11years old, and 2/3 of adolescent population have some degree of periodontal problems. 1/3的6~11岁儿童，2/3青春期人群也有某种程度的牙周问题;Over 200 kinds of bacterial form dental plaque, adhere to the surface of the teeth and gums, and cause periodontal infections. 牙周感染细菌达200余种 Periodontitis Ⅰ Gingivitis bleeding，Deep gingival Pocket 3mm Ⅱ Periodontitis bleeding，swelling，initial bone loss, Deep periodontal Pocket = 5mm Ⅲ major stage bleeding，swelling，major bone loss， Deep periodontal Pocket ＞6mm; Periodontal Pocket: a unique micro-environment牙周袋是独特的微环境 escape the physical separation force 逃逸物理分离力 hard tissue surface 不剥脱更新的硬组织表面 junctional epithelialization, basically not differentiation有结合上皮，基本上不分化 non-keratinizing epithelium 无角化 facultative anaerobic → anaerobic 兼性厌氧→厌氧 nutrition, humidity, pH, Eh 营养、湿度、pH、Eh;第7页/共31页;龈下细菌附着和聚集模式图;Subgingival biofilm formation龈下生物膜形成 Initial colonization早期定居者： actinomyces, streptococci succeeded colonization 微生物交替后： periodontal pathogens 致病微生物定植 Pg，AA, forsythia, T. denticole Fusobacterium nucleatum ;第10页/共31页;1996 confirmed three bacteria for periodontal pathogens : Actinobacillus actinomycetemcomitans (AA) Tannerella forsythia (TF) Porphyromonas gingivalis (Pg) 1996, 牙周致病菌 AA，TF，Pg Recent views change, pathogenic capacity of AA and other culturable or non-culturable bacteria should be confirmed. 近期：AA待证实;50% oral microbial cannot be cultivated and can be identified through e