房颤抗凝治疗药物再认识演示文稿.pptVIP

临床试验中TTR的情况 RE-LY ROCKET AF ARISTOTLE Time in Therapeutic Range (TTR) 64% Mean 55% Median 58% Mean 62% Median 66% C. Michael Gibson, M.S., M.D. Patel MR et al, NEJM 2011; Connolly SJ, et al. N Engl J Med. 2009;361:1139-1151; Granger C et al, N Eng J Med; 2011 Percent of Visits in Range (Traditional Method) Percent of Visits in Range on Given Date (Cross Section Method) Percent of Days in Range (Rosendaal Method) 当前第62页\共有68页\编于星期三\5点 SPORTIF III和V 华法林组与对照组患者结果事件差异 TTR 60% TTR 60-75% TTR 75% 结果 TTR 60% TTR 60-75% TTR75% 死亡率, % 4.2 1.84 1.69 严重出血, % 3.85 1.96 1.58 中风/外周栓塞,%